Semaglutide is a once-weekly, subcutaneous injection for managing type 2 diabetes and weight loss. As a potent glucagon-like peptide (GLP-1) receptor agonist, semaglutide has been studied extensively to understand its mechanism of action and potential benefits in individuals seeking help losing excess weight.
In this article, we will discuss what multiple researchers have shown us about the effects and mechanisms of semaglutide in weight loss patients.
What is Semaglutide?
Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist. GLP-1 is a hormone released in response to eating that helps regulate blood sugar levels by stimulating insulin production, suppressing appetite, and slowing the rate of gastric emptying. It has been approved for use in adults with type 2 diabetes to improve glycemic control with diet and exercise. Additionally, semaglutide is an effective treatment option for weight management.
How Does Semaglutide Work in Obese Patients?
Semaglutide is an injectable drug that helps promote weight loss in patients with obesity. It works by activating a particular type of receptor (called GLP-1 receptors) found in the brain and peripheral organ cells. This triggers a cascade of signals that result in reduced appetite, increased satiety after meals, slower gastric emptying, and decreased caloric intake.
Semaglutide is FDA approved for obese patients with the slightest obesity-related conditions, such as Hypertension, type II diabetes mellitus, and other lipid-related diseases. When given once weekly in obese patients, semaglutide can cause weight loss by:
- Decreasing energy intake
- Hunger suppression
- Controlling eating
- Suppressing food cravings
Multiple studies have also suggested the effects of semaglutide on weight loss. According to a survey conducted in 2021, semaglutide was extremely effective in reducing body weight. During the study, 2.4 mg of semaglutide was administered to 1306 patients, which resulted in significant weight loss compared to those taking a placebo.
Similarly, another study concluded that taking semaglutide for 20 weeks brought a significant reduction in mean body weight along with decreased body mass index (BMI), waist circumference, blood pressure, fasting plasma glucose, HbA1C, and deranged lipid profiles.
How Often Should You Take Semaglutide?
Semaglutide is a medication that can help patients with weight loss. It is administered as a once-weekly injection at a dose of 2.4 mg. Semaglutide helps to increase feelings of fullness, reduce appetite and cravings, and promote healthy metabolic control. The effects of semaglutide on weight loss are usually seen within the first three months of treatment. Patients typically experience an average weight loss of 5-10% during this period, which can lead to improved health outcomes such as lower blood pressure and cholesterol levels.
What are the Side Effects of Semaglutide?
While it can be effective in helping people lose weight, there are some common side effects associated with the use of semaglutide that should be taken into consideration before starting treatment. The most commonly reported side effects include nausea, vomiting, diarrhea, constipation, headache, and abdominal pain.
Some users may also experience increased appetite and dry mouth. In rare cases, more severe side effects such as allergic reactions, changes in vision, or pancreatitis have been reported. It’s essential to speak with your healthcare clinician about any potential risks before starting any treatment with semaglutide.